Research Scientist I, Chemical Development
The Research Scientist I in Chemical Development will be responsible for the process chemistry and scale up activities related to the clinical development and manufacturing of small molecule programs. GBT places a high value on cooperative team dynamics and a positive, can-do work ethic. The ideal candidate thrives in a fast-paced environment where a strong sense of urgency is the norm and exceptional communication and interpersonal skills are needed. Essential Duties and
Responsibilities:
Design and execute synthetic sequences with the intent for optimization and scale up Present results of experiments, independently interpret data, and draw conclusions regarding results of laboratory work Work on complex problems where analysis of situations or data require comprehensive evaluation of many factors Provide technical support to drug substance development, including impurity control strategies and process route development Demonstrate skills in data analysis (ex:
UPLC, HPLC, NMR, mass spec) and ability to evaluate quality of data Accountable to summarize studies, generate, review and approve necessary reports to provide scientifically sound and data-based support of chemical development Apply relevant regulatory guidance (cGMPs, ICH, CFR) in daily work and work planning Up to 20% travel may be needed for scientific project management and monitoring of critical project activities
Qualifications:
PhD. in synthetic organic chemistry, or BS/MS in chemistry with extensive industrial process chemistry experience Chemical development experience with synthesis and crystallizations of heterocycles and chiral molecules preferred Sensitive to timelines and solution oriented Familiar with cGMPs, USP and ICH guidelines and industry best practices A strong chemist who leads with data and understands the requirements for process development and GMP manufacturing Familiarity with physical and chemical characterization of drug substances and drug substance intermediates Excellent written and verbal communications skills required Comfort working in multi-disciplinary teams, learning new skills and proactively solving problems Fit with GBT culture:
Ability to build strong relationships with co-workers of various backgrounds and expertise Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor Values-based leadership consistent with GBT's Core Values Excitement about the vision and mission of GBT Flexibility Integrity NOTE:
This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization. The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position may require you to work onsite or interact in person with customers of the Company and/or work onsite from time to time at the Company's facilities. The Company requires all employees working in its facilities (including attending in-person meetings and events) to be fully vaccinated from COVID-19 (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for a disability/medical condition or sincerely-held religious belief, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. This position requires you to maintain a fully-vaccinated status against COVID-19, subject to reasonable accommodations required by applicable law. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.
Salary Range:
$80K -- $100K
Minimum Qualification
Physical Sciences, Life SciencesEstimated Salary: $20 to $28 per hour based on qualifications.
Responsibilities:
Design and execute synthetic sequences with the intent for optimization and scale up Present results of experiments, independently interpret data, and draw conclusions regarding results of laboratory work Work on complex problems where analysis of situations or data require comprehensive evaluation of many factors Provide technical support to drug substance development, including impurity control strategies and process route development Demonstrate skills in data analysis (ex:
UPLC, HPLC, NMR, mass spec) and ability to evaluate quality of data Accountable to summarize studies, generate, review and approve necessary reports to provide scientifically sound and data-based support of chemical development Apply relevant regulatory guidance (cGMPs, ICH, CFR) in daily work and work planning Up to 20% travel may be needed for scientific project management and monitoring of critical project activities
Qualifications:
PhD. in synthetic organic chemistry, or BS/MS in chemistry with extensive industrial process chemistry experience Chemical development experience with synthesis and crystallizations of heterocycles and chiral molecules preferred Sensitive to timelines and solution oriented Familiar with cGMPs, USP and ICH guidelines and industry best practices A strong chemist who leads with data and understands the requirements for process development and GMP manufacturing Familiarity with physical and chemical characterization of drug substances and drug substance intermediates Excellent written and verbal communications skills required Comfort working in multi-disciplinary teams, learning new skills and proactively solving problems Fit with GBT culture:
Ability to build strong relationships with co-workers of various backgrounds and expertise Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor Values-based leadership consistent with GBT's Core Values Excitement about the vision and mission of GBT Flexibility Integrity NOTE:
This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization. The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position may require you to work onsite or interact in person with customers of the Company and/or work onsite from time to time at the Company's facilities. The Company requires all employees working in its facilities (including attending in-person meetings and events) to be fully vaccinated from COVID-19 (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for a disability/medical condition or sincerely-held religious belief, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. This position requires you to maintain a fully-vaccinated status against COVID-19, subject to reasonable accommodations required by applicable law. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.
Salary Range:
$80K -- $100K
Minimum Qualification
Physical Sciences, Life SciencesEstimated Salary: $20 to $28 per hour based on qualifications.
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