Vice President/ Head of Technical Development, Individualized and Cell Therapy at Roche in South San Francisco, CA
Are you looking for a meaningful role? Are you a senior leader who can build and share an inspiring vision, who can coach leaders and teams to be better, who is a catalyst for change and world class performance, and who knows how to create the architecture that enables their network to be the best in the industry? - We make it possible! At Roche, 94,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity, and diversity. We believe every employee makes a difference. We are passionate about transforming patients' lives. We are courageous in both decision and action, we believe that good business means a better world. Roche Pharma Global Technical Operations (PT) delivers a fast evolving portfolio of new Cell & Gene Therapy (CGT) products to bring new curative treatments to patients. As the Head for Individualized and Cell Therapies Technical Development you will be responsible for the Technical Development of Individualized and Cell Therapies Neoantigen selection by genomics, biosample, and bioinformatics workflows (GB2) Process development Analytical development & analytical operations As a member of the Roche Cell and Gene Therapy (PTC) Leadership Team you will play a key role in developing, shaping and implementing the overall technical strategy of our company in the Cell & Gene Therapy space. Key Responsibilities & Job Requirements Leadership / Management Strategic leadership of process development and analytical development & operations for Individualized Therapies and Cell Therapies Direct functional line manager for a cross-functional team of highly experienced leaders representing several functions:
Biosample, Genomics, Bioinformatics, Nucleic Acid Process Development, Nucleic Acid Therapies Analytical Development & Operations, Cell Therapy Engineering Process Development, Cell Therapy Engineering Analytical Development & Operations Member / Leader of Joint Manufacturing Committee(s) with external partner companies for Individualized Therapies and Cell Therapies thereby developing and executing joint CMC development plans. Technical guidance of Research project teams for Individualized Therapies and Cell Therapies Support and guidance for external partner companies and CMOs in Process Development & Clinical Supply for Roche/Genentech sponsored clinical trials Global responsibilities include close collaboration with counterparts in partner companies to develop robust processes, formulations and analytical methods and with the Roche/Genentech Hillsboro Individualized Therapies manufacturing facility to transfer those processes and methods. Organizational/Functional Leadership In this exciting and dynamic position, you will provide resources and strategic guidance for:
The GB2 (Genomics, Biosample, Bioinformatics) team responsible for the establishment and growth of a new Biosample/Genomics/Bioinformatics function serving cell and gene therapies (CGTs) within PT. This team is responsible for development, implementation and execution of tissue, genomics and bioinformatics workflows that are required to meet clinical supply requirements and process development needs of the growing CGT portfolio The Nucleic Acid Therapies Process & Analytical Development/Operations team responsible for drug substance, drug product process and analytical development groups for nucleic acid based individualized neoantigen specific immunotherapies (iNeSTs). This team provides development of the robust manufacturing processes, formulation, analytical and equipment development, and process/knowledge transfer for iNeSTs The Cell Engineering Therapies Process & Analytical Development (CETD) team responsible for the process and analytical development of cell based autologous and allogeneic therapies. This group of highly technical individuals is responsible for integrated genetic engineering, formulation, analytical and equipment development for cell therapies from research through the commercial stage. Internal/External partnership and global collaboration. This role will also provide strategic direction towards the close collaboration with counterparts in internal Roche/Genentech organizations and partner companies to co-create the cell and gene therapy strategic plan. Education &
Experience:
PhD in Life Sciences or Engineering 15
years or more experience in biotech/pharma industry Working knowledge of nucleic acid biochemistry and advanced genetic engineering of cells Working knowledge of next generation sequencing (NGS) and bioinformatics is desirable Demonstrated ability to lead a team of experienced leaders Demonstrated financial and project management skills Collaboration/Influence Management, Decision Making, Leadership and Results Orientation Ability to work effectively with cross-functional & multi location teams Ability to learn quickly in unfamiliar territory and to deal with ambiguity Demonstrated ability to operate independently under general management direction and make sound decisions and be accountable for those decisions Strong analytical and creative problem solving skills Strong quality orientation in an environment where a quality framework is not fully developed Additional Requirements:
Collaborative Leadership - Ability to strongly influence with or without authority, facilitate groups with diverse perspectives, bring teams to consensus/alignment. High tolerance for ambiguity Ownership and Accountability - Takes accountability for actions, drives results, learns from mistakes. Is direct and truthful and therefore widely trusted - delivers on promises, goals, and expectations. Makes quality decisions and resolves problems rapidly Communication - Ability to communicate effectively at all levels of the organization, teach and present complex and/or new ideas with clarity and simplicity Planning/Organization - Excellent planning and prioritization skills with the ability to multitask and adapt. Able to synthesize large amounts of information. Able to deliver results despite shifting environment. Operate with a high degree of autonomy Are you ready to apply? - We want someone who works with a Network Mindset to follow the Pharma Operating Principle I radically simplify & prioritize for impact. I invest my time in things that accelerate progress for patients. I stop doing things that don't. I re-use with pride. I don't waste resources. I involve the fewest people necessary. Roche is strongly committed to a diverse and inclusive workplace. We strive to build teams that represent a range of backgrounds, perspectives, and skills. Embracing diversity enables us to create a great place to work and to innovate for patients. #LI-AD1 #PTCareers
Salary Range:
$250K -- $500K+
Minimum Qualification
Life SciencesEstimated Salary: $20 to $28 per hour based on qualifications.
Biosample, Genomics, Bioinformatics, Nucleic Acid Process Development, Nucleic Acid Therapies Analytical Development & Operations, Cell Therapy Engineering Process Development, Cell Therapy Engineering Analytical Development & Operations Member / Leader of Joint Manufacturing Committee(s) with external partner companies for Individualized Therapies and Cell Therapies thereby developing and executing joint CMC development plans. Technical guidance of Research project teams for Individualized Therapies and Cell Therapies Support and guidance for external partner companies and CMOs in Process Development & Clinical Supply for Roche/Genentech sponsored clinical trials Global responsibilities include close collaboration with counterparts in partner companies to develop robust processes, formulations and analytical methods and with the Roche/Genentech Hillsboro Individualized Therapies manufacturing facility to transfer those processes and methods. Organizational/Functional Leadership In this exciting and dynamic position, you will provide resources and strategic guidance for:
The GB2 (Genomics, Biosample, Bioinformatics) team responsible for the establishment and growth of a new Biosample/Genomics/Bioinformatics function serving cell and gene therapies (CGTs) within PT. This team is responsible for development, implementation and execution of tissue, genomics and bioinformatics workflows that are required to meet clinical supply requirements and process development needs of the growing CGT portfolio The Nucleic Acid Therapies Process & Analytical Development/Operations team responsible for drug substance, drug product process and analytical development groups for nucleic acid based individualized neoantigen specific immunotherapies (iNeSTs). This team provides development of the robust manufacturing processes, formulation, analytical and equipment development, and process/knowledge transfer for iNeSTs The Cell Engineering Therapies Process & Analytical Development (CETD) team responsible for the process and analytical development of cell based autologous and allogeneic therapies. This group of highly technical individuals is responsible for integrated genetic engineering, formulation, analytical and equipment development for cell therapies from research through the commercial stage. Internal/External partnership and global collaboration. This role will also provide strategic direction towards the close collaboration with counterparts in internal Roche/Genentech organizations and partner companies to co-create the cell and gene therapy strategic plan. Education &
Experience:
PhD in Life Sciences or Engineering 15
years or more experience in biotech/pharma industry Working knowledge of nucleic acid biochemistry and advanced genetic engineering of cells Working knowledge of next generation sequencing (NGS) and bioinformatics is desirable Demonstrated ability to lead a team of experienced leaders Demonstrated financial and project management skills Collaboration/Influence Management, Decision Making, Leadership and Results Orientation Ability to work effectively with cross-functional & multi location teams Ability to learn quickly in unfamiliar territory and to deal with ambiguity Demonstrated ability to operate independently under general management direction and make sound decisions and be accountable for those decisions Strong analytical and creative problem solving skills Strong quality orientation in an environment where a quality framework is not fully developed Additional Requirements:
Collaborative Leadership - Ability to strongly influence with or without authority, facilitate groups with diverse perspectives, bring teams to consensus/alignment. High tolerance for ambiguity Ownership and Accountability - Takes accountability for actions, drives results, learns from mistakes. Is direct and truthful and therefore widely trusted - delivers on promises, goals, and expectations. Makes quality decisions and resolves problems rapidly Communication - Ability to communicate effectively at all levels of the organization, teach and present complex and/or new ideas with clarity and simplicity Planning/Organization - Excellent planning and prioritization skills with the ability to multitask and adapt. Able to synthesize large amounts of information. Able to deliver results despite shifting environment. Operate with a high degree of autonomy Are you ready to apply? - We want someone who works with a Network Mindset to follow the Pharma Operating Principle I radically simplify & prioritize for impact. I invest my time in things that accelerate progress for patients. I stop doing things that don't. I re-use with pride. I don't waste resources. I involve the fewest people necessary. Roche is strongly committed to a diverse and inclusive workplace. We strive to build teams that represent a range of backgrounds, perspectives, and skills. Embracing diversity enables us to create a great place to work and to innovate for patients. #LI-AD1 #PTCareers
Salary Range:
$250K -- $500K+
Minimum Qualification
Life SciencesEstimated Salary: $20 to $28 per hour based on qualifications.
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